動脈硬化 Atherosclerosis

10-8-2013 updated

概要

> 発症の機序は以下の通り(1D)。最初の段階での予防が有効という共通理解がある。

  1. Fatty streak
  2. Endothelial cells activation
  3. Monocyte recruitment
  4. Excessive lipoprotein uptake by macrophage
  5. Formation of proinflammatory lipid-loaded foam cells.

References

  1. Stoletov et al. 2009a. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res 104, 952-960.